MolNFT v1 · #122336 · protein
Crystal structure of the RNA recognition motif of mRNA decay regulator AUF1
5IM0 · Heterogeneous nuclear ribonucleoprotein D0: “Crystal structure of the RNA recognition motif of mRNA decay regulator AUF1”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #122336 on GenesisL1: 3D structure, binding…
- PDB
- 5IM0
- Type
- protein
- Length
- 161 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heterogeneous nuclear ribonucleoprotein D0
- UniProt
- Q14103
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heterogeneous nuclear ribonucleoprotein D0 | protein | 79 | 23% helix, 42% strand | Q14103 |
| B | Heterogeneous nuclear ribonucleoprotein D0 | protein | 82 | 27% helix, 38% strand | Q14103 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 85 | 0.33 | 0.74 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 345 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 modified (engineered).
Compared structures
- 5IM0 · Crystal structure of the RNA recognition motif of mRNA decay regulator AUF1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q14103 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein D0 (Q14103) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14103
- Elsewhere: RCSB PDB 5IM0 · PDBe 5IM0 · UniProt Q14103
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