MolNFT v1 · #122270 · protein

Laminin A2LG45 C-form, apo.

5IK4 · Laminin subunit alpha-2: “Laminin A2LG45 C-form, apo.”. X-ray diffraction, 3 ligands (A2G, NAG, CA), 2 pockets (best druggability 0.52). MolNFT v1 #122270 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5IK4
Type: protein
Length: 379 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Laminin subunit alpha-2
UniProt: Q60675
Ligands: A2G, NAG, CA
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Laminin subunit alpha-2	protein	379	2% helix, 50% strand	Q60675

Ligands and binding sites

A2G · 2-acetamido-2-deoxy-alpha-D-galactopyranose · sugar · chains A
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
CA · Calcium ion · metal · 2 copies · chains A
GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.52	0.82	17	empty
2	180	0.47	0.76	26	empty

Modifications

Observed in the structure: 3 disulfide, 2 glycan (disulfide, N-glycosylation, O-glycosylation).

Compared structures

5IK4 · Laminin A2LG45 C-form, Apo. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q60675
Elsewhere: RCSB PDB 5IK4 · PDBe 5IK4 · UniProt Q60675

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