MolNFT v1 · #122117 · protein

Human PSPC1 homodimer

5IFN · Paraspeckle component 1: “Human PSPC1 homodimer”. X-ray diffraction, 5 pockets (best druggability 0.81). MolNFT v1 #122117 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5IFN
Type: protein
Length: 509 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Paraspeckle component 1
UniProt: Q8WXF1
Pockets: 5 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Paraspeckle component 1	protein	257	41% helix, 23% strand	Q8WXF1
B	Paraspeckle component 1	protein	252	39% helix, 24% strand	Q8WXF1

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1087	0.81	0.82	105	empty
2	185	0.45	0.74	23	empty
3	174	0.42	0.73	24	empty
4	83	0.37	0.76	15	empty
5	75	0.33	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 5228 Å² buried · 91 hydrogen bonds · protein-protein

Compared structures

5IFN · Human PSPC1 Homodimer · the same entry in another collection · chain A against A, TM-score 1.00
Q8WXF1 · AlphaFold monomer V2.0 prediction for paraspeckle component 1 (Q8WXF1) · a predicted model of the same protein · chain B against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WXF1
Elsewhere: RCSB PDB 5IFN · PDBe 5IFN · UniProt Q8WXF1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.