MolNFT v1 · #121993 · protein

Structural analysis of a talin triple domain module, E1794Y, E1797Y, Q1801Y mutant

5IC1 · Talin-1: “Structural analysis of a talin triple domain module, E1794Y, E1797Y, Q1801Y mutant”. X-ray diffraction, 3 pockets (best druggability 0.72). MolNFT v1 #121993 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5IC1
Type: protein
Length: 464 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Talin-1
UniProt: P26039
Pockets: 3 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Talin-1	protein	464	81% helix, 0% strand	P26039

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	703	0.72	0.79	73	EDO
2	73	0.40	0.79	15	empty
3	80	0.31	0.73	18	empty

Compared structures

5IC1 · Structural analysis of a talin triple domain module, E1794Y, E1797Y, Q1801Y mutant · the same entry in another collection · chain A against A, TM-score 1.00
P26039 · AlphaFold monomer V2.0 prediction for talin-1 (P26039) · a predicted model of the same protein · chain A against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26039
Elsewhere: RCSB PDB 5IC1 · PDBe 5IC1 · UniProt P26039

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.