MolNFT v1 · #121984 · protein

Structure of E76Q, a cancer-associated mutation of the oncogenic phosphatase SHP2

5IBS · Tyrosine-protein phosphatase non-receptor type 11: “Structure of E76Q, a cancer-associated mutation of the oncogenic phosphatase SHP2”. X-ray diffraction, 15 pockets (best druggability 0.67). MolNFT v1 #121984 on GenesisL1: 3D…

PDB: 5IBS
Type: protein
Length: 964 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 11
EC: 3.1.3.48
UniProt: Q06124
Pockets: 15 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48)	protein	485	29% helix, 27% strand	Q06124
B	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48)	protein	479	29% helix, 26% strand	Q06124

Pockets

15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	530	0.67	0.78	50	empty
2	401	0.63	0.78	40	empty
3	369	0.62	0.78	36	empty
4	194	0.58	0.81	42	empty
5	129	0.52	0.81	38	empty

Interfaces

1 interface between chains.

A–B · 727 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

5IBS · Structure of E76Q, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06124
Elsewhere: RCSB PDB 5IBS · PDBe 5IBS · UniProt Q06124

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