MolNFT v1 · #121939 · protein

Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with golvatinib (E7050)

5IA5 · Ephrin type-a receptor 2: “Crystal structure of ephrin A2 (EPHA2) receptor protein kinase with golvatinib (E7050)”. X-ray diffraction, 1 ligand (GV0), 2 pockets (best druggability 0.72). MolNFT v1 #121939 on GenesisL1: 3D structure…

PDB: 5IA5
Type: protein
Length: 273 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ephrin type-a receptor 2
EC: 2.7.10.1
UniProt: P29317
Ligands: GV0
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ephrin type-a receptor 2 (EC 2.7.10.1)	protein	273	40% helix, 16% strand	P29317

Ligands and binding sites

GV0 · golvatinib · ligand · chains A
EDO · 1,2-ethanediol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	384	0.72	0.83	37	GV0, EDO
2	276	0.61	0.79	31	empty

Compared structures

5IA5 · Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with golvatinib (E7050) · the same entry in another collection · chain A against A, TM-score 1.00
P29317 · AlphaFold monomer V2.0 prediction for ephrin type-a receptor 2 (P29317) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29317
Elsewhere: RCSB PDB 5IA5 · PDBe 5IA5 · UniProt P29317

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