MolNFT v1 · #121745 · protein
Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of cathepsin L
5I4H · Cathepsin L1: “Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of cathepsin L”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.33). MolNFT v1 #121745 on GenesisL1: 3D…
- PDB
- 5I4H
- Type
- protein
- Length
- 218 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cathepsin L1
- EC
- 3.4.22.15
- UniProt
- P07711
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cathepsin L1 (EC 3.4.22.15) | protein | 106 | 38% helix, 7% strand | P07711 |
| B | Cathepsin L1 (EC 3.4.22.15) | protein | 112 | 16% helix, 32% strand | P07711 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.33 | 0.76 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1549 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 5I4H · Caught in the Act: The Crystal Structure of cleaved Cathepsin L bound to the active site… · the same entry in another collection · chain A against A, TM-score 1.00
- P07711 · AlphaFold monomer V2.0 prediction for procathepsin L (P07711) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07711
- Elsewhere: RCSB PDB 5I4H · PDBe 5I4H · UniProt P07711
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