MolNFT v1 · #121743 · protein
Crystal structure of human nonmuscle myosin 2C motor domain
5I4E · Myosin-14,ALPHA-actinin a: “Crystal structure of human nonmuscle myosin 2C motor domain”. X-ray diffraction, 2 ligands (AOV, MG), 13 pockets (best druggability 0.74). MolNFT v1 #121743 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5I4E
- Type
- protein
- Length
- 959 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-14,ALPHA-actinin a
- UniProt
- Q7Z406, P05095
- Ligands
- AOV, MG
- Pockets
- 13 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin-14,ALPHA-actinin a | protein | 959 | 53% helix, 12% strand | Q7Z406, P05095 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 901 | 0.74 | 0.78 | 66 | empty |
| 2 | 602 | 0.72 | 0.80 | 56 | empty |
| 3 | 520 | 0.69 | 0.79 | 55 | empty |
| 4 | 209 | 0.60 | 0.82 | 36 | AOV, MG |
| 5 | 130 | 0.58 | 0.84 | 23 | empty |
Compared structures
- 5I4E · Crystal Structure of Human Nonmuscle Myosin 2C motor domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q7Z406 · AlphaFold monomer V2.0 prediction for myosin-14 (Q7Z406) · a predicted model of the same protein · chain A against A, TM-score 0.82
- P05095 · AlphaFold monomer V2.0 prediction for alpha-actinin a (P05095) · a predicted model of the same protein · chain A against A, TM-score 0.29
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z406
- Every structure of UniProt P05095
- Elsewhere: RCSB PDB 5I4E · PDBe 5I4E · UniProt Q7Z406 · UniProt P05095
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