MolNFT v1 · #121694 · protein

Crystal structure of TPP1 K170A

5I2Y · Adrenocortical dysplasia protein homolog: “Crystal structure of TPP1 K170A”. X-ray diffraction, 2 pockets (best druggability 0.56). MolNFT v1 #121694 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5I2Y
Type: protein
Length: 284 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adrenocortical dysplasia protein homolog
UniProt: Q96AP0
Pockets: 2 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Adrenocortical dysplasia protein homolog	protein	151	17% helix, 36% strand	Q96AP0
B	Adrenocortical dysplasia protein homolog	protein	133	18% helix, 37% strand	Q96AP0

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	240	0.56	0.78	28	empty
2	66	0.32	0.75	18	empty

Interfaces

1 interface between chains.

A–B · 1434 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

5I2Y · Crystal Structure of TPP1 K170A · the same entry in another collection · chain A against A, TM-score 1.00
Q96AP0 · AlphaFold monomer V2.0 prediction for adrenocortical dysplasia protein homolog (Q96AP0) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96AP0
Elsewhere: RCSB PDB 5I2Y · PDBe 5I2Y · UniProt Q96AP0

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