MolNFT v1 · #121568 · protein

RNA editing tutase 1 from trypanosoma brucei

5HZD · 3' terminal uridylyl transferase: “RNA editing tutase 1 from trypanosoma brucei”. X-ray diffraction, 3 ligands (ZN, SO4, CL), 5 pockets (best druggability 0.66). MolNFT v1 #121568 on GenesisL1: 3D structure, binding sites and…

PDB: 5HZD
Type: protein
Length: 476 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3' terminal uridylyl transferase
UniProt: Q8WQX5
Ligands: ZN, SO4, CL
Pockets: 5 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3' terminal uridylyl transferase	protein	476	47% helix, 13% strand	Q8WQX5

Ligands and binding sites

ZN · Zinc ion · metal · chains A
SO4 · Sulfate ion · ion · 2 copies · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	597	0.66	0.76	53	CL
2	89	0.41	0.78	20	empty
3	94	0.39	0.76	17	empty
4	92	0.37	0.76	17	empty
5	64	0.35	0.78	14	empty

Compared structures

5HZD · RNA Editing TUTase 1 from Trypanosoma brucei · the same entry in another collection · chain A against A, TM-score 1.00
Q8WQX5 · AlphaFold monomer V2.0 prediction for terminal uridylyltransferase 1 (Q8WQX5) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WQX5
Elsewhere: RCSB PDB 5HZD · PDBe 5HZD · UniProt Q8WQX5

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