MolNFT v1 · #12149 · protein
Crystal structure of caspase-7
1K86: “Crystal structure of caspase-7”. X-ray diffraction, 5 pockets (best druggability 0.75). MolNFT v1 #12149 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1K86
- Type
- protein
- Length
- 464 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Caspase-7
- EC
- 3.4.22.-
- UniProt
- P55210
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Caspase-7 (EC 3.4.22.-) | protein | 232 | 29% helix, 23% strand | P55210 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 286 | 0.75 | 0.87 | 50 | empty |
| 2 | 273 | 0.60 | 0.79 | 36 | empty |
| 3 | 218 | 0.54 | 0.78 | 34 | empty |
| 4 | 93 | 0.43 | 0.79 | 22 | empty |
| 5 | 86 | 0.39 | 0.77 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1440 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55210
- Elsewhere: RCSB PDB 1K86 · PDBe 1K86 · UniProt P55210
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