MolNFT v1 · #121441 · protein
Alternative model of the mage-G1 nse-1 complex
5HVQ · Melanoma-associated antigen G1: “Alternative model of the mage-G1 nse-1 complex”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.74). MolNFT v1 #121441 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5HVQ
- Type
- protein
- Length
- 433 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Melanoma-associated antigen G1; Non-structural maintenance of chromosomes element 1…
- EC
- 6.3.2.-
- UniProt
- Q96MG7, Q8WV22
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | Melanoma-associated antigen G1 | protein | 197 | 55% helix, 11% strand | Q96MG7 |
| C | Non-structural maintenance of chromosomes element 1 homolog (EC 6.3.2.-) | protein | 236 | 42% helix, 16% strand | Q8WV22 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 912 | 0.74 | 0.78 | 78 | empty |
| 2 | 97 | 0.47 | 0.80 | 17 | empty |
Interfaces
1 interface between chains.
- D–C · 1508 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 5HVQ · Alternative model of the MAGE-G1 NSE-1 complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q8WV22 · AlphaFold monomer V2.0 prediction for non-structural maintenance of chromosomes element 1… · a predicted model of the same protein · chain C against A, TM-score 1.00
- Q96MG7 · AlphaFold monomer V2.0 prediction for non-structural maintenance of chromosomes element 3… · a predicted model of the same protein · chain D against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96MG7
- Every structure of UniProt Q8WV22
- Elsewhere: RCSB PDB 5HVQ · PDBe 5HVQ · UniProt Q96MG7 · UniProt Q8WV22
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