MolNFT v1 · #121295 · protein
Bovine heart 6-phosphofructo-2-KINASE/FRUCTOSE-2,6-bisphosphatase (PFKFB2)
5HR5 · 6-phosphofructo-2-KINASE/FRUCTOSE-2,6-bisphosphatase 2: “Bovine heart 6-phosphofructo-2-KINASE/FRUCTOSE-2,6-bisphosphatase (PFKFB2)”. X-ray diffraction, 2 ligands (F6P, ADP), 3 pockets (best druggability 0.81). MolNFT v1 #121295 on…
- PDB
- 5HR5
- Type
- protein
- Length
- 424 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 6-phosphofructo-2-KINASE/FRUCTOSE-2,6-bisphosphatase 2
- EC
- 2.7.1.105, 3.1.3.46
- UniProt
- P26285
- Ligands
- F6P, ADP
- Pockets
- 3 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 6-phosphofructo-2-KINASE/FRUCTOSE-2,6-bisphosphatase 2 (EC 2.7.1.105, 3.1.3.46) | protein | 424 | 45% helix, 17% strand | P26285 |
Ligands and binding sites
- F6P · 6-O-phosphono-beta-D-fructofuranose · ligand · chains A
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- DIO · 1,4-diethylene dioxide · additive · chains A
- FLC · Citrate anion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 597 | 0.81 | 0.87 | 84 | DIO, FLC, ADP |
| 2 | 105 | 0.65 | 0.90 | 25 | F6P |
| 3 | 83 | 0.37 | 0.76 | 19 | empty |
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 5HR5 · Bovine Heart 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFKFB2) · the same entry in another collection · chain A against A, TM-score 1.00
- P26285 · AlphaFold monomer V2.0 prediction for 6-phosphofructo-2-KINASE/FRUCTOSE-2,6-bisphosphatase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26285
- Elsewhere: RCSB PDB 5HR5 · PDBe 5HR5 · UniProt P26285
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