MolNFT v1 · #121023 · protein
Crystal structure analysis of CA2+-calmodulin and a C-terminal EAG1 channel fragment
5HIT: “Crystal structure analysis of CA2+-calmodulin and a C-terminal EAG1 channel fragment”. X-ray diffraction, 1 ligand (CA), 1 pocket (best druggability 0.27). MolNFT v1 #121023 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5HIT
- Type
- protein
- Length
- 161 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; Potassium voltage-gated channel subfamily H member 1
- UniProt
- P62149, Q3USQ9
- Ligands
- CA
- Pockets
- 1 · best druggability 0.27
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin | protein | 144 | 63% helix, 4% strand | P62149 |
| B | Potassium voltage-gated channel subfamily H member 1 | protein | 17 | 35% helix, 0% strand | Q3USQ9 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.27 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 551 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5HIT · Crystal Structure Analysis of Ca2+-calmodulin and a C-terminal EAG1 channel fragment · the same entry in another collection · chain A against A, TM-score 1.00
- P62149 · AlphaFold monomer V2.0 prediction for calmodulin (P62149) · a predicted model of the same protein · chain A against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62149
- Every structure of UniProt Q3USQ9
- Elsewhere: RCSB PDB 5HIT · PDBe 5HIT · UniProt P62149 · UniProt Q3USQ9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.