EGFR (L858R, T790M, V948R) in complex with 1-{(3R,4R)-3-[5-chloro-2- (1-methyl-1H-pyrazol-4-ylamino)-7H-PYRROLO[2,3-D]PYRIMIDIN-4- yloxymethyl]-4-methoxy-pyrrolidin-1-YL}PROPENONE (pf-06459988)

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 21% strand (DSSP).

Ligands and binding sites

• 630 · 1-{(3R,4R)-3-[({5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}propan-1-one · ligand · chains A
• SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

• 5HG7 · EGFR (L858R, T790M, V948R) in complex with 1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4… · the same entry in another collection · chain A against A, TM-score 1.00
• P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00533
• Elsewhere: RCSB PDB 5HG7 · PDBe 5HG7 · UniProt P00533