MolNFT v1 · #120900 · protein
Pentameric ligand-gated ion channel elic mutant T28D
5HEW · Gamma-aminobutyric-acid receptor subunit beta-1: “Pentameric ligand-gated ion channel elic mutant T28D”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #120900 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5HEW
- Type
- protein
- Length
- 3,070 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-aminobutyric-acid receptor subunit beta-1
- UniProt
- E0SJQ4
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Gamma-aminobutyric-acid receptor subunit beta-1 | protein | 307 | 35% helix, 33% strand | E0SJQ4 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 223 | 0.84 | 0.96 | 26 | empty |
| 2 | 1063 | 0.83 | 0.84 | 105 | empty |
| 3 | 1031 | 0.83 | 0.84 | 105 | empty |
| 4 | 211 | 0.83 | 0.96 | 24 | empty |
| 5 | 1189 | 0.82 | 0.83 | 104 | empty |
Interfaces
19 interfaces between chains.
- H–I · 2534 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 2495 Ų buried · 21 hydrogen bonds · protein-protein
- G–H · 2491 Ų buried · 23 hydrogen bonds · protein-protein
- C–D · 2477 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 2473 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 5HEW · Pentameric ligand-gated ion channel ELIC mutant T28D · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E0SJQ4
- Elsewhere: RCSB PDB 5HEW · PDBe 5HEW · UniProt E0SJQ4
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