MolNFT v1 · #120888 · protein
Pentameric ligand-gated ion channel glic mutant P246A
5HEH · Proton-gated ion channel: “Pentameric ligand-gated ion channel glic mutant P246A”. X-ray diffraction, 20 pockets (best druggability 0.79). MolNFT v1 #120888 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5HEH
- Type
- protein
- Length
- 1,550 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proton-gated ion channel
- UniProt
- Q7NDN8
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Proton-gated ion channel | protein | 310 | 36% helix, 33% strand | Q7NDN8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1096 | 0.79 | 0.80 | 61 | empty |
| 2 | 76 | 0.70 | 0.95 | 18 | empty |
| 3 | 72 | 0.70 | 0.96 | 18 | empty |
| 4 | 74 | 0.70 | 0.95 | 17 | empty |
| 5 | 65 | 0.69 | 0.96 | 18 | empty |
Interfaces
10 interfaces between chains.
- D–E · 2284 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 2245 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 2244 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 2238 Ų buried · 17 hydrogen bonds · protein-protein
- A–E · 2237 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 5HEH · PDBe 5HEH · UniProt Q7NDN8
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