MolNFT v1 · #120779 · protein
Crystal structure of chaetomium thermophilum NUP145N apd T994A mutant fused to NUP145C N
5HB6 · Nucleoporin NUP145: “Crystal structure of chaetomium thermophilum NUP145N apd T994A mutant fused to NUP145C N”. X-ray diffraction, 1 ligand (SO4), 5 pockets (best druggability 0.59). MolNFT v1 #120779 on GenesisL1: 3D structure…
- PDB
- 5HB6
- Type
- protein
- Length
- 281 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NUP145
- EC
- 3.4.21.-
- UniProt
- G0SAK3
- Ligands
- SO4
- Pockets
- 5 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoporin NUP145 (EC 3.4.21.-) | protein | 138 | 20% helix, 30% strand | G0SAK3 |
| B | Nucleoporin NUP145 (EC 3.4.21.-) | protein | 143 | 16% helix, 29% strand | G0SAK3 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 365 | 0.59 | 0.76 | 51 | empty |
| 2 | 300 | 0.58 | 0.77 | 33 | empty |
| 3 | 78 | 0.31 | 0.73 | 18 | SO4 |
| 4 | 50 | 0.27 | 0.74 | 15 | SO4 |
| 5 | 61 | 0.27 | 0.72 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 612 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5HB6 · Crystal structure of Chaetomium thermophilum Nup145N APD T994A mutant fused to Nup145C N · the same entry in another collection · chain A against A, TM-score 1.00
- G0SAK3 · AlphaFold monomer V2.0 prediction for nucleoporin NUP145 (G0SAK3) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SAK3
- Elsewhere: RCSB PDB 5HB6 · PDBe 5HB6 · UniProt G0SAK3
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