MolNFT v1 · #120773 · protein
Crystal structure of chaetomium thermophilum NUP170 ctd-NUP145N complex
5HB0 · Nucleoporin NUP170: “Crystal structure of chaetomium thermophilum NUP170 ctd-NUP145N complex”. X-ray diffraction, 20 pockets (best druggability 0.77). MolNFT v1 #120773 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5HB0
- Type
- protein
- Length
- 2,119 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NUP170; Nucleoporin NUP145
- EC
- 3.4.21.-
- UniProt
- G0S7B6, G0SAK3
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 6 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Nucleoporin NUP170 | protein | 520 | 74% helix, 0% strand | G0S7B6 |
| A | Nucleoporin NUP170 | protein | 508 | 75% helix, 0% strand | G0S7B6 |
| C | Nucleoporin NUP170 | protein | 519 | 74% helix, 0% strand | G0S7B6 |
| D | Nucleoporin NUP170 | protein | 502 | 76% helix, 0% strand | G0S7B6 |
| E, F, H | Nucleoporin NUP145 (EC 3.4.21.-) | protein | 17 | 0% helix, 0% strand | G0SAK3 |
| G | Nucleoporin NUP145 (EC 3.4.21.-) | protein | 19 | 0% helix, 0% strand | G0SAK3 |
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 915 | 0.77 | 0.80 | 89 | empty |
| 2 | 594 | 0.69 | 0.78 | 63 | empty |
| 3 | 587 | 0.65 | 0.76 | 54 | empty |
| 4 | 543 | 0.63 | 0.75 | 49 | empty |
| 5 | 324 | 0.56 | 0.75 | 32 | empty |
Interfaces
12 interfaces between chains.
- A–D · 1439 Ų buried · 5 hydrogen bonds · protein-protein
- C–G · 994 Ų buried · 14 hydrogen bonds · protein-protein
- B–E · 822 Ų buried · 9 hydrogen bonds · protein-protein
- A–F · 814 Ų buried · 10 hydrogen bonds · protein-protein
- D–H · 800 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5HB0 · Crystal structure of Chaetomium thermophilum Nup170 CTD-Nup145N complex · the same entry in another collection · chain H against H, TM-score 1.00
- G0S7B6 · AlphaFold monomer V2.0 prediction for nucleoporin NUP170 (G0S7B6) · a predicted model of the same protein · chain D against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S7B6
- Every structure of UniProt G0SAK3
- Elsewhere: RCSB PDB 5HB0 · PDBe 5HB0 · UniProt G0S7B6 · UniProt G0SAK3
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