Crystal structure of human galectin-7 in complex with taztdg

Structure

x-ray diffraction · 2 distinct chains · 2% helix, 54% strand (DSSP).

Ligands and binding sites

• TGZ · (2~{S},3~{R},4~{S},5~{R},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,4,5-triol · ligand · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 774 Ų buried · 17 hydrogen bonds · protein-protein

Compared structures

• 5H9S · Crystal Structure of Human Galectin-7 in Complex with TAZTDG · the same entry in another collection · chain A against A, TM-score 1.00
• P47929 · AlphaFold monomer V2.0 prediction for galectin-7 (P47929) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P47929
• Elsewhere: RCSB PDB 5H9S · PDBe 5H9S · UniProt P47929