MolNFT v1 · #120662 · protein

Crystal structure of elongation factor 2

5H7J: “Crystal structure of elongation factor 2”. X-ray diffraction, 1 ligand (GCP), 18 pockets (best druggability 0.79). MolNFT v1 #120662 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5H7J
Type: protein
Length: 1,378 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Elongation factor 2
UniProt: O59521
Ligands: GCP
Pockets: 18 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Elongation factor 2	protein	686	37% helix, 28% strand	O59521
B	Elongation factor 2	protein	692	37% helix, 28% strand	O59521

Ligands and binding sites

GCP · Phosphomethylphosphonic acid guanylate ester · ligand · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

18 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	880	0.79	0.82	76	empty
2	962	0.77	0.79	73	empty
3	356	0.53	0.73	38	empty
4	77	0.45	0.81	17	empty
5	91	0.45	0.80	18	empty

Interfaces

1 interface between chains.

A–B · 769 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

5H7J · Crystal structure of Elongation factor 2 · the same entry in another collection · chain A against A, TM-score 1.00
O59521 · AlphaFold monomer V2.0 prediction for elongation factor 2 (O59521) · a predicted model of the same protein · chain B against A, TM-score 0.63

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O59521
Elsewhere: RCSB PDB 5H7J · PDBe 5H7J · UniProt O59521

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.