MolNFT v1 · #120651 · protein

Crystal structure of the PKA-protein a fusion protein

5H77 · Camp-dependent protein kinase type II-alpha regulatory…: “Crystal structure of the PKA-protein a fusion protein”. X-ray diffraction, 12 pockets (best druggability 0.70). MolNFT v1 #120651 on GenesisL1: 3D structure, binding sites…

PDB: 5H77
Type: protein
Length: 1,000 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding…
UniProt: P13861, P38507
Pockets: 12 · best druggability 0.70

Structure

x-ray diffraction · 9 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, F	Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a	protein	84	73% helix, 0% strand	P13861, P38507
B, E	Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a	protein	85	78% helix, 0% strand	P13861, P38507
D	Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a	protein	86	71% helix, 0% strand	P13861, P38507
G	Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a	protein	79	73% helix, 0% strand	P13861, P38507
H	Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a	protein	84	71% helix, 0% strand	P13861, P38507
I	Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a	protein	82	71% helix, 0% strand	P13861, P38507
J	Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a	protein	83	73% helix, 0% strand	P13861, P38507
K	Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a	protein	81	73% helix, 0% strand	P13861, P38507
L	Camp-dependent protein kinase type II-alpha regulatory SUBUNIT,IMMUNOGLOBULIN G-binding protein a	protein	83	78% helix, 0% strand	P13861, P38507

Pockets

12 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	479	0.70	0.80	53	empty
2	435	0.69	0.80	52	empty
3	498	0.67	0.78	42	empty
4	356	0.65	0.79	41	empty
5	259	0.64	0.81	36	empty

Interfaces

21 interfaces between chains.

E–F · 1049 Å² buried · 4 hydrogen bonds · protein-protein
I–J · 1017 Å² buried · 1 hydrogen bond · protein-protein
C–D · 1011 Å² buried · 3 hydrogen bonds · protein-protein
A–B · 1005 Å² buried · 3 hydrogen bonds · protein-protein
G–H · 986 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

5H77 · Crystal structure of the PKA-protein A fusion protein · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13861
Every structure of UniProt P38507
Elsewhere: RCSB PDB 5H77 · PDBe 5H77 · UniProt P13861 · UniProt P38507

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