MolNFT v1 · #120560 · protein
Structural and mechanistical studies of the nuclear import by importin-alpha
5H43 · Importin subunit alpha-1: “Structural and mechanistical studies of the nuclear import by importin-alpha”. X-ray diffraction, 3 pockets (best druggability 0.42). MolNFT v1 #120560 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5H43
- Type
- protein
- Length
- 453 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; Histone acetyltransferase KAT8
- EC
- 2.3.1.48
- UniProt
- P52292, Q9H7Z6
- Pockets
- 3 · best druggability 0.42
Structure
x-ray diffraction · 3 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-1 | protein | 428 | 75% helix, 0% strand | P52292 |
| B | Histone acetyltransferase KAT8 (EC 2.3.1.48) | protein | 10 | 30% helix, 0% strand | Q9H7Z6 |
| C | Histone acetyltransferase KAT8 (EC 2.3.1.48) | protein | 15 | 0% helix, 0% strand | Q9H7Z6 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.42 | 0.79 | 13 | empty |
| 2 | 121 | 0.40 | 0.75 | 22 | empty |
| 3 | 57 | 0.33 | 0.77 | 12 | empty |
Interfaces
2 interfaces between chains.
- A–C · 1045 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 794 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 5H43 · Structural and mechanistical studies of the nuclear import by Importin-alpha · the same entry in another collection · chain A against A, TM-score 1.00
- P52292 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52292) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9H7Z6 · AlphaFold monomer V2.0 prediction for histone acetyltransferase KAT8 (Q9H7Z6) · a predicted model of the same protein · chain B against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52292
- Every structure of UniProt Q9H7Z6
- Elsewhere: RCSB PDB 5H43 · PDBe 5H43 · UniProt P52292 · UniProt Q9H7Z6
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