MolNFT v1 · #120545 · protein

Solution structure of human gelsolin protein domain 1 at pH 5.0

5H3M: “Solution structure of human gelsolin protein domain 1 at pH 5.0”. Solution nmr, 2 pockets (best druggability 0.66). MolNFT v1 #120545 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5H3M
Type: protein
Length: 133 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gelsolin
UniProt: P06396
Pockets: 2 · best druggability 0.66

Structure

solution nmr · 1 distinct chain · 23% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gelsolin	protein	133	23% helix, 25% strand	P06396

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	154	0.66	0.87	32	empty
2	145	0.45	0.76	25	empty

Compared structures

5H3M · Solution structure of human Gelsolin protein domain 1 at pH 5.0 · the same entry in another collection · chain A against A, TM-score 1.00
P06396 · AlphaFold monomer V2.0 prediction for gelsolin (P06396) · a predicted model of the same protein · chain A against A, TM-score 0.77

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06396
Elsewhere: RCSB PDB 5H3M · PDBe 5H3M · UniProt P06396

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