MolNFT v1 · #120525 · protein
Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0
5H32 · Structural protein E: “Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0”. Electron microscopy, 5 pockets (best druggability 0.38). MolNFT v1 #120525 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5H32
- Type
- protein
- Length
- 1,917 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural protein E; C10 IgG heavy chain variable region; C10 IgG light chain variable…
- UniProt
- A0A024B7W1
- Pockets
- 5 · best druggability 0.38
Structure
electron microscopy · 3 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, B | Structural protein E | protein | 403 | 0% helix, 0% strand | A0A024B7W1 |
| G, K, I | C10 IgG heavy chain variable region | protein | 127 | 0% helix, 0% strand | — |
| H, L, M | C10 IgG light chain variable region | protein | 109 | 0% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.38 | 0.73 | 27 | empty |
| 2 | 66 | 0.31 | 0.73 | 19 | empty |
| 3 | 67 | 0.30 | 0.72 | 20 | empty |
| 4 | 59 | 0.29 | 0.72 | 17 | empty |
| 5 | 51 | 0.28 | 0.73 | 17 | empty |
Interfaces
11 interfaces between chains.
- A–C · 239 Ų buried · 0 hydrogen bonds · protein-protein
- B–L · 95 Ų buried · 0 hydrogen bonds · protein-protein
- I–M · 95 Ų buried · 0 hydrogen bonds · protein-protein
- A–H · 73 Ų buried · 0 hydrogen bonds · protein-protein
- G–H · 71 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5H32 · Cryo-EM structure of zika virus complexed with Fab C10 at pH 5.0 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A024B7W1
- Elsewhere: RCSB PDB 5H32 · PDBe 5H32 · UniProt A0A024B7W1
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