MolNFT v1 · #120523 · protein
Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5
5H30 · Structural protein E: “Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5”. Electron microscopy, 7 pockets (best druggability 0.43). MolNFT v1 #120523 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5H30
- Type
- protein
- Length
- 2,445 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural protein E; Strutural protein M; IgG C10 heavy chain; IgG C10 light chain
- UniProt
- A0A024B7W1
- Pockets
- 7 · best druggability 0.43
Structure
electron microscopy · 4 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, B | Structural protein E | protein | 504 | 0% helix, 0% strand | A0A024B7W1 |
| D, E, F | Strutural protein M | protein | 75 | 0% helix, 0% strand | A0A024B7W1 |
| G, K, I | IgG C10 heavy chain | protein | 127 | 0% helix, 0% strand | — |
| H, L, M | IgG C10 light chain | protein | 109 | 0% helix, 0% strand | — |
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 149 | 0.43 | 0.73 | 40 | empty |
| 2 | 98 | 0.36 | 0.72 | 29 | empty |
| 3 | 93 | 0.35 | 0.72 | 20 | empty |
| 4 | 83 | 0.34 | 0.72 | 24 | empty |
| 5 | 83 | 0.33 | 0.72 | 24 | empty |
Interfaces
19 interfaces between chains.
- C–F · 297 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 265 Ų buried · 0 hydrogen bonds · protein-protein
- B–E · 222 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 204 Ų buried · 0 hydrogen bonds · protein-protein
- A–F · 125 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5H30 · Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A024B7W1
- Elsewhere: RCSB PDB 5H30 · PDBe 5H30 · UniProt A0A024B7W1
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