MolNFT v1 · #120456 · protein

TRAF1-tank complex

5H10 · TNF receptor-associated factor 1: “TRAF1-tank complex”. X-ray diffraction, 6 pockets (best druggability 0.74). MolNFT v1 #120456 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5H10
Type: protein
Length: 598 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TNF receptor-associated factor 1; Traf family member-associated nf-kappab activator
UniProt: Q13077
Pockets: 6 · best druggability 0.74

Structure

x-ray diffraction · 6 distinct chains · 31% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TNF receptor-associated factor 1	protein	192	31% helix, 28% strand	Q13077
B	TNF receptor-associated factor 1	protein	190	33% helix, 28% strand	Q13077
C	TNF receptor-associated factor 1	protein	195	32% helix, 29% strand	Q13077
D	Traf family member-associated nf-kappab activator	protein	6	0% helix, 33% strand	—
E	Traf family member-associated nf-kappab activator	protein	7	0% helix, 29% strand	—
F	Traf family member-associated nf-kappab activator	protein	8	0% helix, 25% strand	—

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	802	0.74	0.78	71	empty
2	341	0.62	0.78	42	empty
3	110	0.39	0.75	17	empty
4	80	0.31	0.73	13	empty
5	73	0.30	0.73	17	empty

Interfaces

6 interfaces between chains.

A–C · 1251 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 1207 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 1190 Å² buried · 9 hydrogen bonds · protein-protein
C–F · 523 Å² buried · 10 hydrogen bonds · protein-protein
B–E · 441 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

5H10 · TRAF1-TANk complex · the same entry in another collection · chain F against F, TM-score 1.00
Q13077 · AlphaFold monomer V2.0 prediction for TNF receptor-associated factor 1 (Q13077) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13077
Elsewhere: RCSB PDB 5H10 · PDBe 5H10 · UniProt Q13077

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