MolNFT v1 · #12035 · protein

Crystal structure of tRNA-guanine transglycosylase (tgt) complexed with 2,6-diamino-8-propylsulfanylmethyl-3H-quinazoline-4-one

1K4H · TRNA-guanine-transglycosylase: “Crystal structure of tRNA-guanine transglycosylase (tgt) complexed with…”. X-ray diffraction, 2 ligands (APQ, ZN), 2 pockets (best druggability 0.65). MolNFT v1 #12035 on GenesisL1: 3D structure…

PDB: 1K4H
Type: protein
Length: 372 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TRNA-guanine-transglycosylase
EC: 2.4.2.29
UniProt: P28720
Ligands: APQ, ZN
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TRNA-guanine-transglycosylase (EC 2.4.2.29)	protein	372	46% helix, 19% strand	P28720

Ligands and binding sites

APQ · 2,6-diamino-8-propylsulfanylmethyl-3H-quinazoline-4-one · ligand · chains A
ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	252	0.65	0.82	41	APQ
2	72	0.36	0.77	17	empty

Compared structures

1K4H · CRYSTAL STRUCTURE OF TRNA-GUANINE TRANSGLYCOSYLASE (TGT) COMPLEXED WITH… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28720
Elsewhere: RCSB PDB 1K4H · PDBe 1K4H · UniProt P28720

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