MolNFT v1 · #120277 · protein
Crystal structure of arginine-bound CASTOR1 from homo sapiens
5GV2 · Gats-like protein 3: “Crystal structure of arginine-bound CASTOR1 from homo sapiens”. X-ray diffraction, 2 ligands (ARG, MG), 8 pockets (best druggability 0.43). MolNFT v1 #120277 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5GV2
- Type
- protein
- Length
- 611 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gats-like protein 3
- UniProt
- Q8WTX7
- Ligands
- ARG, MG
- Pockets
- 8 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Gats-like protein 3 | protein | 307 | 30% helix, 32% strand | Q8WTX7 |
| A | Gats-like protein 3 | protein | 304 | 30% helix, 33% strand | Q8WTX7 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.43 | 0.81 | 18 | empty |
| 2 | 135 | 0.43 | 0.76 | 23 | empty |
| 3 | 121 | 0.42 | 0.76 | 25 | empty |
| 4 | 72 | 0.40 | 0.79 | 20 | empty |
| 5 | 119 | 0.39 | 0.74 | 25 | empty |
Interfaces
1 interface between chains.
- C–A · 975 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 5GV2 · Crystal structure of Arginine-bound CASTOR1 from Homo sapiens · the same entry in another collection · chain C against C, TM-score 1.00
- Q8WTX7 · AlphaFold monomer V2.0 prediction for cytosolic arginine sensor for MTORC1 subunit 1… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WTX7
- Elsewhere: RCSB PDB 5GV2 · PDBe 5GV2 · UniProt Q8WTX7
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