MolNFT v1 · #120188 · protein
Crystal structure of CASTOR1-arginine
5GS9 · Gats-like protein 3: “Crystal structure of CASTOR1-arginine”. X-ray diffraction, 1 ligand (ARG), 15 pockets (best druggability 0.79). MolNFT v1 #120188 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5GS9
- Type
- protein
- Length
- 1,175 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gats-like protein 3
- UniProt
- Q8WTX7
- Ligands
- ARG
- Pockets
- 15 · best druggability 0.79
Structure
x-ray diffraction · 4 distinct chains · 29% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gats-like protein 3 | protein | 309 | 29% helix, 31% strand | Q8WTX7 |
| B | Gats-like protein 3 | protein | 286 | 31% helix, 34% strand | Q8WTX7 |
| C | Gats-like protein 3 | protein | 294 | 28% helix, 32% strand | Q8WTX7 |
| D | Gats-like protein 3 | protein | 286 | 28% helix, 34% strand | Q8WTX7 |
Ligands and binding sites
- ARG · Arginine · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1148 | 0.79 | 0.80 | 103 | empty |
| 2 | 50 | 0.66 | 0.96 | 22 | ARG |
| 3 | 154 | 0.48 | 0.77 | 28 | empty |
| 4 | 222 | 0.46 | 0.74 | 27 | empty |
| 5 | 139 | 0.43 | 0.75 | 26 | empty |
Interfaces
5 interfaces between chains.
- C–D · 992 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 943 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 758 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 90 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 50 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- Q8WTX7 · AlphaFold monomer V2.0 prediction for cytosolic arginine sensor for MTORC1 subunit 1… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WTX7
- Elsewhere: RCSB PDB 5GS9 · PDBe 5GS9 · UniProt Q8WTX7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.