MolNFT v1 · #120090 · protein
Structure of a 16-mer protein nanocage fabricated from its 24-mer analogue by subunit interface redesign
5GOU · Ferritin heavy chain: “Structure of a 16-mer protein nanocage fabricated from its 24-mer analogue by subunit interface redesign”. X-ray diffraction, 20 pockets (best druggability 0.76). MolNFT v1 #120090 on GenesisL1: 3D structure…
- PDB
- 5GOU
- Type
- protein
- Length
- 2,225 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferritin heavy chain
- EC
- 1.16.3.1
- UniProt
- P02794
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 13 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ferritin heavy chain (EC 1.16.3.1) | protein | 141 | 69% helix, 1% strand | P02794 |
| B, D | Ferritin heavy chain (EC 1.16.3.1) | protein | 131 | 64% helix, 1% strand | P02794 |
| C | Ferritin heavy chain (EC 1.16.3.1) | protein | 148 | 70% helix, 1% strand | P02794 |
| F | Ferritin heavy chain (EC 1.16.3.1) | protein | 152 | 72% helix, 1% strand | P02794 |
| E | Ferritin heavy chain (EC 1.16.3.1) | protein | 132 | 66% helix, 1% strand | P02794 |
| H | Ferritin heavy chain (EC 1.16.3.1) | protein | 145 | 70% helix, 1% strand | P02794 |
| G | Ferritin heavy chain (EC 1.16.3.1) | protein | 134 | 65% helix, 1% strand | P02794 |
| J | Ferritin heavy chain (EC 1.16.3.1) | protein | 146 | 71% helix, 1% strand | P02794 |
| I, K | Ferritin heavy chain (EC 1.16.3.1) | protein | 133 | 68% helix, 1% strand | P02794 |
| L | Ferritin heavy chain (EC 1.16.3.1) | protein | 146 | 68% helix, 1% strand | P02794 |
| N | Ferritin heavy chain (EC 1.16.3.1) | protein | 144 | 70% helix, 1% strand | P02794 |
| M, O | Ferritin heavy chain (EC 1.16.3.1) | protein | 133 | 71% helix, 1% strand | P02794 |
| P | Ferritin heavy chain (EC 1.16.3.1) | protein | 143 | 72% helix, 1% strand | P02794 |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.76 | 0.99 | 15 | empty |
| 2 | 63 | 0.75 | 0.99 | 15 | empty |
| 3 | 56 | 0.73 | 0.99 | 15 | empty |
| 4 | 60 | 0.73 | 0.98 | 15 | empty |
| 5 | 52 | 0.72 | 0.99 | 14 | empty |
Interfaces
32 interfaces between chains.
- F–E · 1522 Ų buried · 22 hydrogen bonds · protein-protein
- H–G · 1519 Ų buried · 25 hydrogen bonds · protein-protein
- N–M · 1515 Ų buried · 26 hydrogen bonds · protein-protein
- P–O · 1496 Ų buried · 20 hydrogen bonds · protein-protein
- J–I · 1491 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 5GOU · Structure of a 16-mer protein nanocage fabricated from its 24-mer analogue by subunit… · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02794
- Elsewhere: RCSB PDB 5GOU · PDBe 5GOU · UniProt P02794
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