MolNFT v1 · #119990 · protein
Tl-gal with lnt
5GLT · Galectin: “Tl-gal with lnt”. X-ray diffraction, 3 ligands (GAL, BGC, NAG), 5 pockets (best druggability 0.60). MolNFT v1 #119990 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5GLT
- Type
- protein
- Length
- 556 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Galectin
- Ligands
- GAL, BGC, NAG
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 1% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Galectin | protein | 278 | 1% helix, 54% strand | — |
Ligands and binding sites
- GAL · beta-D-galactopyranose · sugar · 6 copies · chains A, B
- BGC · beta-D-glucopyranose · sugar · 3 copies
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 166 | 0.60 | 0.83 | 32 | empty |
| 2 | 171 | 0.59 | 0.83 | 32 | empty |
| 3 | 91 | 0.37 | 0.75 | 18 | empty |
| 4 | 51 | 0.30 | 0.76 | 17 | empty |
| 5 | 54 | 0.28 | 0.75 | 19 | empty |
Modifications
Observed in the structure: 1 glycan (glycosylation).
Compared structures
- 5GLT · Tl-gal with LNT · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5GLT · PDBe 5GLT
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