MolNFT v1 · #119826 · protein

Crystal structure of human protein O-mannose beta-1,2-N- acetylglucosaminyltransferase form I

5GGG · Protein O-linked-mannose beta-1,2-N…: “Crystal structure of human protein O-mannose beta-1,2-N- acetylglucosaminyltransferase form I”. X-ray diffraction, 5 pockets (best druggability 0.51). MolNFT v1 #119826 on GenesisL1: 3D…

PDB: 5GGG
Type: protein
Length: 536 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein O-linked-mannose beta-1,2-N- acetylglucosaminyltransferase 1
EC: 2.4.1.-
UniProt: Q8WZA1
Pockets: 5 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein O-linked-mannose beta-1,2-N- acetylglucosaminyltransferase 1 (EC 2.4.1.-)	protein	536	27% helix, 26% strand	Q8WZA1

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	129	0.51	0.80	25	empty
2	272	0.50	0.74	33	empty
3	69	0.45	0.82	17	empty
4	93	0.35	0.74	15	empty
5	89	0.33	0.73	19	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5GGG · Crystal structure of human protein O-mannose beta-1,2-N-acetylglucosaminyltransferase… · the same entry in another collection · chain A against A, TM-score 1.00
Q8WZA1 · AlphaFold monomer V2.0 prediction for protein O-linked-mannose… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WZA1
Elsewhere: RCSB PDB 5GGG · PDBe 5GGG · UniProt Q8WZA1

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