UniProt Q8WZA1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (Q8WZA1)
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (UniProt Q8WZA1), EC 2.4.1.-: 20 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 46 pockets. Binding sites, druggability and…
- UniProt
- Q8WZA1
- Protein
- Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
- EC
- 2.4.1.-
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 46 · 5 records with a druggable one
Structures
21 records of Q8WZA1 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GGF | Crystal structure of human protein O-mannose beta-1,2-N-acetylglucosaminyltransferase form II | x-ray diffraction | A, B, C | — | 17 (best 0.71) |
| 5GGF | Crystal structure of human protein O-mannose beta-1,2-N- acetylglucosaminyltransferase form II | x-ray diffraction | A, B, C | — | — |
| 5GGG | Crystal structure of human protein O-mannose beta-1,2-N-acetylglucosaminyltransferase form I | x-ray diffraction | A | — | 5 (best 0.51) |
| 5GGG | Crystal structure of human protein O-mannose beta-1,2-N- acetylglucosaminyltransferase form I | x-ray diffraction | A | — | — |
| 5GGI | Crystal structure of human protein O-mannose beta-1,2-N-acetylglucosaminyltransferase in complex… | x-ray diffraction | A, B | UDP, MN, PO4, MAN | 10 (best 0.80) |
| 5GGI | Crystal structure of human protein O-mannose beta-1,2-N- acetylglucosaminyltransferase in complex… | x-ray diffraction | A, B | — | — |
| 5GGJ | Crystal structure of N-terminal domain of human protein O-mannose… | x-ray diffraction | A, B | PNA | — |
| 5GGJ | Crystal structure of N-terminal domain of human protein O-mannose… | x-ray diffraction | A, B | — | — |
| 5GGK | Crystal structure of N-terminal domain of human protein O-mannose… | x-ray diffraction | A, B | MBE | 2 (best 0.44) |
| 5GGK | Crystal structure of N-terminal domain of human protein O-mannose… | x-ray diffraction | A, B | — | — |
| 5GGL | Crystal structure of N-terminal domain of human protein O-mannose… | x-ray diffraction | A, B | 6ZC | 2 (best 0.43) |
| 5GGL | Crystal structure of N-terminal domain of human protein O-mannose… | x-ray diffraction | A, B | — | — |
| 5GGN | Crystal structure of N-terminal domain of human protein O-mannose… | x-ray diffraction | A, B | LEC | — |
| 5GGN | Crystal structure of N-terminal domain of human protein O-mannose… | x-ray diffraction | A, B | — | — |
| 5GGO | Crystal structure of N-terminal domain of human protein O-mannose… | x-ray diffraction | A, B | LEC, NGA | 1 (best 0.42) |
| 5GGO | Crystal structure of N-terminal domain of human protein O-mannose… | x-ray diffraction | A, B | — | — |
| 5GGP | Crystal structure of N-terminal domain of human protein O-mannose… | x-ray diffraction | A, B | MAN, NAG, NA | 2 (best 0.64) |
| 5GGP | Crystal structure of N-terminal domain of human protein O-mannose… | x-ray diffraction | A, B | — | — |
| 5XFC | Serial femtosecond X-ray structure of a stem domain of human O-mannose… | x-ray diffraction | A, B | MBE | 2 (best 0.50) |
| 5XFC | Serial femtosecond X-ray structure of a stem domain of human O-mannose… | x-ray diffraction | A, B | MBE | — |
| Q8WZA1 | AlphaFold monomer V2.0 prediction for protein O-linked-mannose… | predicted | A | — | 5 (best 0.76) |
Ligands
- MBE · 4-nitrophenyl beta-D-mannopyranoside · in 3 records
- LEC · 4-nitrophenyl 2-acetamido-2-deoxy-beta-D-glucopyranoside · in 2 records
- MAN · alpha-D-mannopyranose · in 2 records
- 6ZC · 4-nitrophenyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside · in 1 record
- MN · Manganese (II) ion · in 1 record
- NA · Sodium ion · in 1 record
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
- NGA · 2-acetamido-2-deoxy-beta-D-galactopyranose · in 1 record
- PNA · 4-nitrophenyl alpha-D-mannopyranoside · in 1 record
- PO4 · Phosphate ion · in 1 record
- UDP · Uridine-5'-diphosphate · in 1 record
Experiment against prediction
- 5GGI chain A against the predicted model Q8WZA1: TM-score 1.00, RMSD 0.39 Å
- 5GGI chain A against the predicted model Q8WZA1: TM-score 1.00, RMSD 0.39 Å
- 5GGI chain B against the predicted model Q8WZA1: TM-score 1.00, RMSD 0.46 Å
- 5GGI chain B against the predicted model Q8WZA1: TM-score 1.00, RMSD 0.46 Å
- 5GGP chain A against the predicted model Q8WZA1: TM-score 1.00, RMSD 0.31 Å
- 5GGP chain A against the predicted model Q8WZA1: TM-score 1.00, RMSD 0.31 Å
- 5GGN chain B against the predicted model Q8WZA1: TM-score 0.99, RMSD 0.38 Å
- 5GGN chain B against the predicted model Q8WZA1: TM-score 0.99, RMSD 0.38 Å
- 5GGO chain B against the predicted model Q8WZA1: TM-score 0.99, RMSD 0.39 Å
- 5GGO chain B against the predicted model Q8WZA1: TM-score 0.99, RMSD 0.39 Å
Elsewhere
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