MolNFT v1 · #119737 · protein
Crystal structure of A190T mutant of human hippocalcin at 2.5 a resolution
5G58 · Neuron-specific calcium-binding protein hippocalcin: “Crystal structure of A190T mutant of human hippocalcin at 2.5 a resolution”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.77). MolNFT v1 #119737 on GenesisL1…
- PDB
- 5G58
- Type
- protein
- Length
- 368 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neuron-specific calcium-binding protein hippocalcin
- UniProt
- P84074
- Ligands
- CA
- Pockets
- 2 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neuron-specific calcium-binding protein hippocalcin | protein | 184 | 64% helix, 3% strand | P84074 |
| E | Neuron-specific calcium-binding protein hippocalcin | protein | 184 | 64% helix, 3% strand | P84074 |
Ligands and binding sites
- CA · Calcium ion · metal · 6 copies · chains A, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1062 | 0.77 | 0.78 | 75 | empty |
| 2 | 666 | 0.73 | 0.79 | 48 | empty |
Interfaces
1 interface between chains.
- A–E · 947 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 5G58 · Crystal structure of A190T mutant of human hippocalcin AT 2.5 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
- P84074 · AlphaFold monomer V2.0 prediction for neuron-specific calcium-binding protein hippocalcin… · a predicted model of the same protein · chain E against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84074
- Elsewhere: RCSB PDB 5G58 · PDBe 5G58 · UniProt P84074
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