MolNFT v1 · #119177 · protein

Crystal structure of human complement C3B at 2.8 ångström resolution

5FO7 · Complement C3 beta chain: “Crystal structure of human complement C3B at 2.8 ångström resolution”. X-ray diffraction, 1 ligand (NAG), 19 pockets (best druggability 0.77). MolNFT v1 #119177 on GenesisL1: 3D structure, binding sites…

PDB: 5FO7
Type: protein
Length: 1,537 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Complement C3 beta chain; Complement C3B alpha' chain
UniProt: P01024
Ligands: NAG
Pockets: 19 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Complement C3 beta chain	protein	637	7% helix, 52% strand	P01024
B	Complement C3B alpha' chain	protein	900	26% helix, 32% strand	P01024

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

19 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1065	0.77	0.79	85	empty
2	466	0.74	0.83	44	empty
3	363	0.67	0.81	55	empty
4	403	0.63	0.78	49	empty
5	213	0.62	0.82	34	empty

Interfaces

1 interface between chains.

A–B · 5211 Å² buried · 67 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

5FO7 · Crystal Structure of Human Complement C3b at 2.8 Angstrom resolution · the same entry in another collection · chain B against B, TM-score 1.00
P01024 · AlphaFold monomer V2.0 prediction for complement C3 (P01024) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01024
Elsewhere: RCSB PDB 5FO7 · PDBe 5FO7 · UniProt P01024

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.