Crystal structure of human CD45 extracellular region, domains D1-D2

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 49% strand (DSSP).

Ligands and binding sites

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 9 copies · chains A, B
• HG · Mercury (II) ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 840 Ų buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 disulfide, 9 glycan (disulfide, N-glycosylation).

Compared structures

• 5FN7 · Crystal structure of human CD45 extracellular region, domains d1-d2 · the same entry in another collection · chain A against A, TM-score 1.00
• P08575 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase C… · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P08575
• Elsewhere: RCSB PDB 5FN7 · PDBe 5FN7 · UniProt P08575