UniProt P08575
Receptor-type tyrosine-protein phosphatase C (P08575)
Receptor-type tyrosine-protein phosphatase C (UniProt P08575), EC 3.1.3.48: 11 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P08575
- Protein
- Receptor-type tyrosine-protein phosphatase C
- EC
- 3.1.3.48
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 22 · 3 records with a druggable one
Structures
12 records of P08575 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YGR | Crystal structure of the tandem phosphatase domain of RPTP CD45 | x-ray diffraction | A, B | — | — |
| 1YGR | Crystal structure of the tandem phosphatase domain of rptp CD45 | x-ray diffraction | A, B | — | — |
| 1YGU | Crystal structure of the tandem phosphatase domains of RPTP CD45 with a pTyr peptide | x-ray diffraction | A, B | — | — |
| 1YGU | Crystal structure of the tandem phosphatase domains of rptp CD45 with a ptyr peptide | x-ray diffraction | A, B | — | — |
| 5FMV | Crystal structure of human CD45 extracellular region, domains d1-d4 | x-ray diffraction | A, B | NAG, SO4 | 5 (best 0.66) |
| 5FMV | Crystal structure of human CD45 extracellular region, domains D1-D4 | x-ray diffraction | A, B | — | — |
| 5FN6 | Crystal structure of human CD45 extracellular region, domains d1-d3 | x-ray diffraction | A | NAG | — |
| 5FN6 | Crystal structure of human CD45 extracellular region, domains D1-D3 | x-ray diffraction | A | — | — |
| 5FN7 | Crystal structure of human CD45 extracellular region, domains d1-d2 | x-ray diffraction | A, B | NAG, HG | — |
| 5FN7 | Crystal structure of human CD45 extracellular region, domains D1-D2 | x-ray diffraction | A, B | — | — |
| 8VSE | Cryo-EM structure of human CD45 extracellular region in complex with adenoviral protein E3/49K | electron microscopy | A, B | NAG | 9 (best 0.52) |
| P08575 | AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase C (P08575) | predicted | A | — | 8 (best 0.79) |
Ligands
Experiment against prediction
- 1YGU chain A against the predicted model P08575: TM-score 0.99, RMSD 1.00 Å
- 1YGU chain A against the predicted model P08575: TM-score 0.99, RMSD 1.00 Å
- 1YGR chain B against the predicted model P08575: TM-score 0.99, RMSD 1.02 Å
- 1YGR chain B against the predicted model P08575: TM-score 0.99, RMSD 1.02 Å
- 1YGR chain A against the predicted model P08575: TM-score 0.98, RMSD 1.30 Å
- 1YGR chain A against the predicted model P08575: TM-score 0.98, RMSD 1.30 Å
- 1YGU chain B against the predicted model P08575: TM-score 0.98, RMSD 1.39 Å
- 1YGU chain B against the predicted model P08575: TM-score 0.98, RMSD 1.39 Å
- 5FN6 chain A against the predicted model P08575: TM-score 0.95, RMSD 1.43 Å
- 5FN6 chain A against the predicted model P08575: TM-score 0.95, RMSD 1.43 Å
Elsewhere
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