MolNFT v1 · #11907 · protein
Crystal structure of a soluble monomeric form of CLIC1 at 1.4 ångströms
1K0M · Chloride intracellular channel protein 1: “Crystal structure of a soluble monomeric form of CLIC1 at 1.4 ångströms”. X-ray diffraction, 5 pockets (best druggability 0.49). MolNFT v1 #11907 on GenesisL1: 3D structure, binding sites…
- PDB
- 1K0M
- Type
- protein
- Length
- 471 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chloride intracellular channel protein 1
- UniProt
- O00299
- Pockets
- 5 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chloride intracellular channel protein 1 | protein | 235 | 49% helix, 9% strand | O00299 |
| B | Chloride intracellular channel protein 1 | protein | 236 | 48% helix, 9% strand | O00299 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 191 | 0.49 | 0.76 | 36 | empty |
| 2 | 239 | 0.48 | 0.74 | 23 | empty |
| 3 | 58 | 0.41 | 0.82 | 21 | empty |
| 4 | 84 | 0.32 | 0.73 | 18 | empty |
| 5 | 66 | 0.27 | 0.72 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 51 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1K0M · Crystal structure of a soluble monomeric form of CLIC1 at 1.4 angstroms · the same entry in another collection · chain A against A, TM-score 1.00
- O00299 · AlphaFold monomer V2.0 prediction for chloride intracellular channel protein 1 (O00299) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00299
- Elsewhere: RCSB PDB 1K0M · PDBe 1K0M · UniProt O00299
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