MolNFT v1 · #118778 · protein
Mouse importin alpha: dengue 3 NS5 C-terminal nls peptide complex
5FC8 · Nonstructural protein 5: “Mouse importin alpha: dengue 3 NS5 C-terminal nls peptide complex”. X-ray diffraction, 2 pockets (best druggability 0.49). MolNFT v1 #118778 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5FC8
- Type
- protein
- Length
- 440 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nonstructural protein 5; Importin subunit alpha-1
- UniProt
- B6VDJ7, P52293
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Nonstructural protein 5 | protein | 13 | 0% helix, 0% strand | B6VDJ7 |
| E | Importin subunit alpha-1 | protein | 427 | 74% helix, 0% strand | P52293 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.49 | 0.83 | 13 | empty |
| 2 | 64 | 0.27 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- C–E · 1030 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 5FC8 · Mouse importin alpha: Dengue 3 NS5 C-terminal NLS peptide complex · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B6VDJ7
- Every structure of UniProt P52293
- Elsewhere: RCSB PDB 5FC8 · PDBe 5FC8 · UniProt B6VDJ7 · UniProt P52293
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