MolNFT v1 · #118769 · protein

Crystal structure of ctspd

5FBY · Separase: “Crystal structure of ctspd”. X-ray diffraction, 6 pockets (best druggability 0.52). MolNFT v1 #118769 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5FBY
Type: protein
Length: 501 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Separase; Cleaved peptide
UniProt: G0SHM3
Pockets: 6 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Separase	protein	490	47% helix, 14% strand	G0SHM3
B	Cleaved peptide	protein	11	36% helix, 0% strand	—

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	189	0.52	0.78	31	empty
2	155	0.50	0.78	21	empty
3	62	0.37	0.78	15	empty
4	101	0.36	0.74	22	empty
5	54	0.32	0.77	21	empty

Interfaces

1 interface between chains.

A–B · 701 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

5FBY · Crystal structure of ctSPD · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0SHM3
Elsewhere: RCSB PDB 5FBY · PDBe 5FBY · UniProt G0SHM3

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