MolNFT v1 · #118506 · protein
Crystal structure of MYO7B N-MYTH4-ferm-SH3 in complex with ANKS4B cen
5F3Y · Unconventional myosin-viib: “Crystal structure of MYO7B N-MYTH4-ferm-SH3 in complex with ANKS4B cen”. X-ray diffraction, 7 pockets (best druggability 0.69). MolNFT v1 #118506 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5F3Y
- Type
- protein
- Length
- 562 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unconventional myosin-viib; Ankyrin repeat and SAM domain-containing protein 4B
- UniProt
- Q99MZ6, Q8K3X6
- Pockets
- 7 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unconventional myosin-viib | protein | 549 | 43% helix, 18% strand | Q99MZ6 |
| B | Ankyrin repeat and SAM domain-containing protein 4B | protein | 13 | 0% helix, 31% strand | Q8K3X6 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.69 | 0.93 | 21 | empty |
| 2 | 280 | 0.65 | 0.82 | 41 | empty |
| 3 | 95 | 0.43 | 0.79 | 16 | empty |
| 4 | 70 | 0.40 | 0.80 | 15 | empty |
| 5 | 62 | 0.40 | 0.80 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 680 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5F3Y · Crystal Structure of Myo7b N-MyTH4-FERM-SH3 in complex with Anks4b CEN · the same entry in another collection · chain A against A, TM-score 1.00
- Q99MZ6 · AlphaFold monomer V2.0 prediction for unconventional myosin-viib (Q99MZ6) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q8K3X6 · AlphaFold monomer V2.0 prediction for ankyrin repeat and SAM domain- containing protein… · a predicted model of the same protein · chain B against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99MZ6
- Every structure of UniProt Q8K3X6
- Elsewhere: RCSB PDB 5F3Y · PDBe 5F3Y · UniProt Q99MZ6 · UniProt Q8K3X6
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