MolNFT v1 · #118494 · protein
Structure of myostatin in complex with humanized RK35 antibody
5F3H · Humanized RK35 antibody heavy chain: “Structure of myostatin in complex with humanized RK35 antibody”. X-ray diffraction, 20 pockets (best druggability 0.70). MolNFT v1 #118494 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5F3H
- Type
- protein
- Length
- 2,099 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Humanized RK35 antibody heavy chain; Humanized RK35 antibody light chain…
- UniProt
- O14793
- Pockets
- 20 · best druggability 0.70
Structure
x-ray diffraction · 7 distinct chains · 7% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Humanized RK35 antibody heavy chain | protein | 207 | 6% helix, 52% strand | — |
| B | Humanized RK35 antibody light chain | protein | 212 | 6% helix, 50% strand | — |
| C, E | Humanized RK35 antibody heavy chain | protein | 211 | 6% helix, 53% strand | — |
| D, F, H | Humanized RK35 antibody light chain | protein | 211 | 6% helix, 50% strand | — |
| G | Humanized RK35 antibody heavy chain | protein | 208 | 6% helix, 52% strand | — |
| I, J, L | GROWTH/DIFFERENTIATION factor 8 | protein | 104 | 13% helix, 46% strand | O14793 |
| K | GROWTH/DIFFERENTIATION factor 8 | protein | 105 | 16% helix, 48% strand | O14793 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 607 | 0.70 | 0.78 | 85 | empty |
| 2 | 488 | 0.68 | 0.79 | 63 | empty |
| 3 | 477 | 0.67 | 0.78 | 49 | empty |
| 4 | 488 | 0.66 | 0.78 | 52 | empty |
| 5 | 275 | 0.63 | 0.81 | 38 | empty |
Interfaces
18 interfaces between chains.
- E–F · 1769 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 1731 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 1717 Ų buried · 17 hydrogen bonds · protein-protein
- K–L · 1698 Ų buried · 16 hydrogen bonds · protein-protein
- G–H · 1671 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 34 disulfide (disulfide).
Compared structures
- 5F3H · Structure of myostatin in complex with humanized RK35 antibody · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14793
- Elsewhere: RCSB PDB 5F3H · PDBe 5F3H · UniProt O14793
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