UniProt O14793
Growth/differentiation factor 8 (O14793)
Growth/differentiation factor 8 (UniProt O14793): 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14793
- Protein
- Growth/differentiation factor 8
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 10 · 1 record with a druggable one
Structures
11 records of O14793 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5F3B | Structure of myostatin in complex with chimeric RK35 antibody | x-ray diffraction | C, D | — | — |
| 5F3B | Structure of myostatin in complex with chimeric RK35 antibody | x-ray diffraction | C, D | — | — |
| 5F3H | Structure of myostatin in complex with humanized RK35 antibody | x-ray diffraction | I, J, K, L | — | — |
| 5F3H | Structure of myostatin in complex with humanized RK35 antibody | x-ray diffraction | I, J, K, L | — | — |
| 5NTU | Crystal Structure of human Pro-myostatin Precursor at 2.6 A Resolution | x-ray diffraction | A, B | CL | — |
| 5NTU | Crystal structure of human pro-myostatin precursor at 2.6 a resolution | x-ray diffraction | A, B | CL | — |
| 5NXS | Crystal Structure of Human Pro-myostatin Precursor at 4.2 A Resolution with Experimental Phases… | x-ray diffraction | A, B | — | — |
| 5NXS | Crystal structure of human pro-myostatin precursor at 4.2 a resolution with experimental phases… | x-ray diffraction | A, B | — | — |
| 6UMX | Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by… | x-ray diffraction | A, B | — | 10 (best 0.72) |
| 6UMX | Structural basis for specific inhibition of extracellular activation of PRO/LATENT myostatin by… | x-ray diffraction | A, B | — | — |
| O14793 | AlphaFold monomer V2.0 prediction for GROWTH/DIFFERENTIATION factor 8 (O14793) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 2 records
Experiment against prediction
- 5NTU chain A against the predicted model O14793: TM-score 0.94, RMSD 1.81 Å
- 5NTU chain A against the predicted model O14793: TM-score 0.94, RMSD 1.81 Å
- 5NTU chain B against the predicted model O14793: TM-score 0.94, RMSD 1.67 Å
- 5NTU chain B against the predicted model O14793: TM-score 0.94, RMSD 1.67 Å
- 5F3H chain L against the predicted model O14793: TM-score 0.81, RMSD 1.39 Å
- 5F3H chain L against the predicted model O14793: TM-score 0.81, RMSD 1.39 Å
- 5F3H chain I against the predicted model O14793: TM-score 0.81, RMSD 1.43 Å
- 5F3H chain I against the predicted model O14793: TM-score 0.81, RMSD 1.43 Å
- 5F3H chain J against the predicted model O14793: TM-score 0.80, RMSD 1.64 Å
- 5F3H chain J against the predicted model O14793: TM-score 0.80, RMSD 1.64 Å
Elsewhere
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