MolNFT v1 · #118452 · protein

Crystal structure of fat domain of focal adhesion kinase (fak) bound to the transcription factor MEF2C

5F28: “Crystal structure of fat domain of focal adhesion kinase (fak) bound to the transcription factor MEF2C”. X-ray diffraction, 4 pockets (best druggability 0.76). MolNFT v1 #118452 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 5F28
Type: protein
Length: 676 residues
Chains: 7
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MEF2C; Focal adhesion kinase 1
UniProt: Q8CFN5, P34152
Pockets: 4 · best druggability 0.76

Structure

x-ray diffraction · 5 distinct chains · 67% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MEF2C	protein	70	49% helix, 21% strand	Q8CFN5
B	MEF2C	protein	73	47% helix, 22% strand	Q8CFN5
C, D	MEF2C	protein	72	50% helix, 21% strand	Q8CFN5
E, F	Focal adhesion kinase 1	protein	128	83% helix, 0% strand	P34152
G	Focal adhesion kinase 1	protein	133	83% helix, 0% strand	P34152

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	917	0.76	0.79	77	empty
2	361	0.59	0.76	41	empty
3	282	0.59	0.78	52	empty
4	88	0.35	0.75	17	empty

Interfaces

10 interfaces between chains.

A–B · 2608 Å² buried · 42 hydrogen bonds · protein-protein
C–D · 2551 Å² buried · 38 hydrogen bonds · protein-protein
E–F · 2140 Å² buried · 12 hydrogen bonds · protein-protein
E–G · 796 Å² buried · 4 hydrogen bonds · protein-protein
B–F · 571 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

5F28 · Crystal structure of FAT domain of Focal Adhesion Kinase (FAK) bound to the transcription… · the same entry in another collection · chain G against G, TM-score 1.00
P34152 · AlphaFold monomer V2.0 prediction for focal adhesion kinase 1 (P34152) · a predicted model of the same protein · chain G against A, TM-score 0.96
Q8CFN5 · AlphaFold monomer V2.0 prediction for myocyte-specific enhancer factor 2C (Q8CFN5) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8CFN5
Every structure of UniProt P34152
Elsewhere: RCSB PDB 5F28 · PDBe 5F28 · UniProt Q8CFN5 · UniProt P34152

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