Research workbench
Crystal structure of fat domain of focal adhesion kinase (fak) bound to the transcription factor MEF2C
Analyse Crystal structure of fat domain of focal adhesion kinase (fak) bound to the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5F28
- Type
- protein
- Length
- 676 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MEF2C; Focal adhesion kinase 1
- UniProt
- Q8CFN5, P34152
- Pockets
- 4 · best druggability 0.76
Structure
x-ray diffraction · 5 distinct chains · 67% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MEF2C | protein | 70 | 49% helix, 21% strand | Q8CFN5 |
| B | MEF2C | protein | 73 | 47% helix, 22% strand | Q8CFN5 |
| C, D | MEF2C | protein | 72 | 50% helix, 21% strand | Q8CFN5 |
| E, F | Focal adhesion kinase 1 | protein | 128 | 83% helix, 0% strand | P34152 |
| G | Focal adhesion kinase 1 | protein | 133 | 83% helix, 0% strand | P34152 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 917 | 0.76 | 0.79 | 77 | empty |
| 2 | 361 | 0.59 | 0.76 | 41 | empty |
| 3 | 282 | 0.59 | 0.78 | 52 | empty |
| 4 | 88 | 0.35 | 0.75 | 17 | empty |
Interfaces
10 interfaces between chains.
- A–B · 2608 Ų buried · 42 hydrogen bonds · protein-protein
- C–D · 2551 Ų buried · 38 hydrogen bonds · protein-protein
- E–F · 2140 Ų buried · 12 hydrogen bonds · protein-protein
- E–G · 796 Ų buried · 4 hydrogen bonds · protein-protein
- B–F · 571 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5F28 · Crystal structure of FAT domain of Focal Adhesion Kinase (FAK) bound to the transcription… · the same entry in another collection · chain G against G, TM-score 1.00
- P34152 · AlphaFold monomer V2.0 prediction for focal adhesion kinase 1 (P34152) · a predicted model of the same protein · chain G against A, TM-score 0.96
- Q8CFN5 · AlphaFold monomer V2.0 prediction for myocyte-specific enhancer factor 2C (Q8CFN5) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8CFN5
- Every structure of UniProt P34152
- Elsewhere: RCSB PDB 5F28 · PDBe 5F28 · UniProt Q8CFN5 · UniProt P34152
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