MolNFT v1 · #118416 · protein

Structure of eav NSP11 K170A mutant at 3.19A

5F17 · Non-structural protein 11: “Structure of eav NSP11 K170A mutant at 3.19A”. X-ray diffraction, 9 pockets (best druggability 0.62). MolNFT v1 #118416 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5F17
Type: protein
Length: 1,286 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Non-structural protein 11
UniProt: P19811
Pockets: 9 · best druggability 0.62

Structure

x-ray diffraction · 3 distinct chains · 13% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Non-structural protein 11	protein	219	14% helix, 36% strand	P19811
D, F	Non-structural protein 11	protein	209	13% helix, 33% strand	P19811
E	Non-structural protein 11	protein	211	12% helix, 30% strand	P19811

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	351	0.62	0.78	42	empty
2	237	0.61	0.80	33	empty
3	333	0.57	0.76	49	empty
4	380	0.57	0.74	44	empty
5	92	0.51	0.83	28	empty

Interfaces

10 interfaces between chains.

C–E · 775 Å² buried · 3 hydrogen bonds · protein-protein
B–F · 723 Å² buried · 6 hydrogen bonds · protein-protein
A–E · 581 Å² buried · 2 hydrogen bonds · protein-protein
B–D · 580 Å² buried · 2 hydrogen bonds · protein-protein
B–E · 414 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

5F17 · Structure of EAV NSP11 K170A mutant at 3.19A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19811
Elsewhere: RCSB PDB 5F17 · PDBe 5F17 · UniProt P19811

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