Research workbench
Structure of eav NSP11 K170A mutant at 3.19A
Analyse Structure of eav NSP11 K170A mutant at 3.19A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5F17
- Type
- protein
- Length
- 1,286 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural protein 11
- UniProt
- P19811
- Pockets
- 9 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 13% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Non-structural protein 11 | protein | 219 | 14% helix, 36% strand | P19811 |
| D, F | Non-structural protein 11 | protein | 209 | 13% helix, 33% strand | P19811 |
| E | Non-structural protein 11 | protein | 211 | 12% helix, 30% strand | P19811 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 351 | 0.62 | 0.78 | 42 | empty |
| 2 | 237 | 0.61 | 0.80 | 33 | empty |
| 3 | 333 | 0.57 | 0.76 | 49 | empty |
| 4 | 380 | 0.57 | 0.74 | 44 | empty |
| 5 | 92 | 0.51 | 0.83 | 28 | empty |
Interfaces
10 interfaces between chains.
- C–E · 775 Ų buried · 3 hydrogen bonds · protein-protein
- B–F · 723 Ų buried · 6 hydrogen bonds · protein-protein
- A–E · 581 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 580 Ų buried · 2 hydrogen bonds · protein-protein
- B–E · 414 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5F17 · Structure of EAV NSP11 K170A mutant at 3.19A · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19811
- Elsewhere: RCSB PDB 5F17 · PDBe 5F17 · UniProt P19811
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