MolNFT v1 · #118407 · protein
Crystal structure of human copper homeostatic proteins ATOX1
5F0W · Copper transport protein ATOX1: “Crystal structure of human copper homeostatic proteins ATOX1”. X-ray diffraction, 1 ligand (AG), 1 pocket (best druggability 0.28). MolNFT v1 #118407 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5F0W
- Type
- protein
- Length
- 272 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Copper transport protein ATOX1
- UniProt
- O00244
- Ligands
- AG
- Pockets
- 1 · best druggability 0.28
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Copper transport protein ATOX1 | protein | 68 | 34% helix, 32% strand | O00244 |
Ligands and binding sites
- AG · Silver ion · metal · 8 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.28 | 0.74 | 12 | empty |
Interfaces
4 interfaces between chains.
- B–D · 465 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 161 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 148 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 14 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5F0W · Crystal structure of human copper homeostatic proteins atox1 · the same entry in another collection · chain D against D, TM-score 1.00
- O00244 · AlphaFold monomer V2.0 prediction for copper transport protein ATOX1 (O00244) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00244
- Elsewhere: RCSB PDB 5F0W · PDBe 5F0W · UniProt O00244
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