MolNFT v1 · #118330 · protein
Crystal structure of fructokinase from vibrio cholerae O395 in fructose, ADP, beryllium trifluoride and calcium ion bound form
5EYN: “Crystal structure of fructokinase from vibrio cholerae O395 in fructose, ADP, beryllium trifluoride and…”. X-ray diffraction, 5 ligands (BEF, ADP, FRU), 2 pockets (best druggability 0.75). MolNFT v1 #118330 on GenesisL1: 3D…
- PDB
- 5EYN
- Type
- protein
- Length
- 306 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructokinase
- EC
- 2.7.1.4
- UniProt
- A0A0H3AER7
- Ligands
- BEF, ADP, FRU, CA, NA
- Pockets
- 2 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fructokinase (EC 2.7.1.4) | protein | 306 | 42% helix, 23% strand | A0A0H3AER7 |
Ligands and binding sites
- BEF · Beryllium trifluoride ion · ligand · chains A
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- FRU · beta-D-fructofuranose · sugar · chains A
- CA · Calcium ion · metal · chains A
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 435 | 0.75 | 0.85 | 66 | FRU, CA, BEF, ADP |
| 2 | 89 | 0.42 | 0.79 | 12 | empty |
Compared structures
- 5EYN · Crystal structure of Fructokinase from Vibrio cholerae O395 in fructose, ADP, Beryllium… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0H3AER7
- Elsewhere: RCSB PDB 5EYN · PDBe 5EYN · UniProt A0A0H3AER7
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